
Screening
- determination of cell specificity
- efficacy compared to the current references
- in vitro study of antitumor effects (cell lines, primary cultures)
- in vivo study of antitumor activity (rodent)
- ex vivo study of anti-diabetic activity (islets of Langerhans assay, ...)
- in vivo study of new anti-diabetic drugs in rodent (Insulin, glycemia studies)
Study of action mechanism
- therapeutic class
- cell cycle
- anti-angiogenic effects
- anti-hormonal effects
- cytotoxicity
- hematotoxicity (human progenitors)
- clonogenic assay (human cell lines)
- apoptosis studies
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